Meekatharra is the major supply centre for the pastoral and mining in the Murchison region.

The townsite is 35 kilometres north-north-east of Nannine where the first gold rush on the Murchison Goldfield occurred in 1890. In late 1895, prospectors Meehan, Porter and Soych pegged a claim near Meekatharra Spring, the aboriginal name of a watering point that had appeared on maps since 1885. It is from this spring that the townsite’s name is derived. It is believed that the name means ‘place of little water’.